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 Creme Complete


     Perrin’s Creme Complete contains the greatest combination and highest concentration of cancer fighting vitamins and antioxidants of any of our creams and moisturizers (excluding Perrin’s Blend, which is an ointment).  With extended use of the Creme Complete we have seen abnormal skin tissue, such as sun damaged areas and age spots, peel away and return to normal healthy looking skin.  The Creme Complete has also had a positive effect on Lichen Sclerosis.  We’ve added the  antioxidants CoQ10 and resveratrol for even more protection against aging and free-radical damage.

Ingredients: Pure Aloe Vera, Vegetable Glycerin, Grape Seed oil, Almond oil, organic Castor oil, organic Olive oil, organic Safflower oil & Soy oil.  Beeswax, organic Cocoa Butter, Honey, Vegetable derived Emulsifing Wax, lecithin, Vitamin A, D, E, & C, N-Acetyl Cysteine, Alpha Lipoic Acid, Resveratrol, CoQ10, Grape Seed extract, Biotin, Lavender oil, Peppermint oil, Frankincense oil, Germanium oil, Orange oil, Lemon oil, cornstarch, cream of tartar, and rice flour.

$43.99   2 oz

Click here to purchase Creme Complete

 

 

For a better online shopping and viewing experience, and for more up-to-date information please visit our new site!

www.perrinnaturals.com


Perrin’s Blend is a thick, sticky, honey based, burgundy colored ointment that is used to treat specific lesions.  It can’t be easily spread over large areas.  The Creme Complete on the other hand is an antioxidant moisturizer that can be used over large areas of skin.  With extended use of the Creme Complete we have seen abnormal skin tissue, such as age spots, sun spots, and possible Actinic Keratosis peel away and return to healthy, normal looking skin. Our customers have also found relief from Lichen Sclerosis with use of the Creme Complete. The pictures below are of a 66 year old woman.  The pictures were taken about 6 months apart.
     -The red abrasions in the picture on the left were initially flat “age spots”.  After using the Creme Complete for 2 1/2 months they began to lift up, turn red, and peel away.  This is when the first picture was taken.  The second picture was taken 6 months later. 


Before

After extended use of the Creme Complete


Testimonies involving the Creme Complete

Concerning a Lichen Sclerosis Lesion, involving Perrin’s Blend and the Creme Complete, from Eva in Norway

Hello Judy,
 
The order arrived to our adress here in Norway Septermber 24, and my daugther (18) started using Perrins Blend that very evening. At first using the product gave her a burning kind of feeling, but that stopped after a few days.
 
Some weeks before we ordered Perrins Blend + The Creme Complete from your store, my daugther went to see her doctor and he found out she had Lichen Skleroses and was given steroids as treatment.
She was very depressed by the diagnosis, and so I surfed the Internet to learn more and look for alternative ways of treatment. Then we found and ordered your wonderful products.
 
My daugther has been using both creams every day since they arrived.  Two weeks ago, she went to her doctor again to check out how she was doing regading Lichen Skleroses. Her doctor didn't know anything about her using your products. After he was done with the  examination he called me into his office (my daugther was still there). He looked at us and said: " This must be some kind of a miracle . Your daugther doesn't have Lichen Scleroses at all. I don't understand it, so maybee I was wrong the first time she was here..."  He seemed a little confused about it all.
 
My daugther looked at me and then told the doctor that she had used "Perrins Blend" and "Creme Complete" for about two months. He told us that he really  didn't believe in that kind of alternative treatment, but as long as no Lichen Scleroses was present any more he couldn't deny the effect...
 
Now my daughter uses the Creme Complete almost every day and is feeling well.
After I send you this message i will go to your internet store to make a new order of your wonderful products.
 
Best regards,
Eva


Concerning Lichen Sclerosis, involving the Creme Complete, from Suzanne in Florida
Dear James, Jim, and Judy,   I am writing to thank you for sharing your God-given products with others. I have had amazing results using the Perrin's Complete [Creme Complete] for a condition known as Lichen Sclerosis. I had been reluctantly using steroid creams for 2 years with only marginal success, and frequent,painful exacerbations. I had been searching for something with fewer side effects, long term, and more effective pain relief. Imagine my joy in finding incredible and lasting improvement with use of Perrin's Complete [Creme Complete]! I did try the Perrin's Blend initially, but found the burning, in acutely excoriated areas, much too uncomfortable, so I switched to the Complete [Creme Complete}. I found almost immediate relief from the burning, and a much quicker reduction in symptoms, and now experiencing a full remission. I will never be without this "miracle"product" nearby,and I thank you from the bottom of my heart! May the heavens smile on you and yours,always.  Suzanne

Concerning a Lichen Sclerosis Lesion, involving Perrin’s Blend and the Creme Complete, from Roberta in Ohio
Hi Judy,
Just writing to let you know the Perrins Blend and Creme Complete works wonderfully.
I have a disease called Lichen Schelrosis, it is a disease of the skin that affects many women around the vulva area leaving lesions as it does it damage.  LS in itself does not cause Cancer but the Lesions it leaves behind can go into cancer and that was what happened to me over 2 1/2 years ago requiring extensive surgery in that area.  I was diagnosed with stage 2 Sqameous Cell carcinoma cancer and the doctor was able to remove all of that and was doing well till about a couple of months ago when I had noticed more lesions forming and not wanting to heal - that is the first sign that something is not right.  Not too anxious to go thru the surgery again I began looking and praying for God to lead me to something natural to use. I began searching websites for products and was drawn to your website twice.
I had called you and talked with you about the product.   I found out that no one else that you knew of had used the cremes in the area in which I was going to.  But I decided to try it anyway because  I knew it was all natural and nothing was in it that would hurt me.  So I ordered some Perrins blend and creme complete and proceeded to use the Perrins blend at night because it is a little guey. I used the Creme complete during the day when I went to work to keep the high antioxidents on it all the time.  To start with the Perrings Blend did burn quite a bit the first fifteenn minutes after applying.  There was an initial burning for about 2 weeks then the more I used it the  less it burned and I could feel that it was making the lesions smaller and it was like pieces of the lesion were starting to flake off and the terrible itching that is associated with LS was not as bad.  I had went to my Doctor during this time frame and he had scheduled me for a Biopsy and to remove the lesion on May 15th of this year.  I told him that the lesions were starting to feel better, it didn't hurt to touch them anymore and I wasn't sure it would be necessary for him to do that,  but he insisted we proceed so I agreed knowing that it would also give me piece of mind to know for sure that the cremes I had been using were in fact working .  May 15th the surgery and biopsies were done at the Cleveland clinic and he told me it would be 7 days before they knew.  On the 7th day I was anxious to know so I called and talked with the nurse and she said the tests came back and I was a number 1 on the scale  -     zero being normal skin, 1 being low moderate risk, 2 being medium moderate risk, 3 being high moderate risk and 4 being cancer.  The nurse also made the comment she was sure the cremes I had been using were definitely working because I had dropped 2 points from the other biopsies that had been taken in previous months.  She said if she were me she would keep using those cremes. Also  when I had went back for post op appointment she had made the comment again before she left the room that I should keep using the cremes that there was definitely an inprovement. This is also the first time in the 2 1/2 years that he is going to let me come back to see him in 6 months rather than every 3 months.
 You can use this on your website testimony postings if It will help someone else.  Cause it sure helped me and healing from the surgery was not so bad - it seemed to heal fast and I also attribute that to the cremes.  LS is a terrible disease and no one knows what causes it yet and I have been told that not enough people have it to be a priority in finding a cure. So thank goodness for good caring people like you and your family.  God Bless you!!
 
Roberta - Ohio

Concerning Lichen Sclerosis, involving the Creme Complete, from Brandie in Ohio
Hi,
My name is Brandie. I am composing this testimony by my own free will, and not for capital or monetary  gain.  I have been struggling with Lichen Sclerosus probably longer than I can remember. But it became severe in January 2009.I had all the classic symptoms: Itching, scratching, burning, bleeding,the  toad skin, and white marks on my vulva.  I had become so distraught I often wondered if I could have my female parts removed all together. I had tried EVERYTHING. First it was yeast infection creams,then anti fungal cream,then hydrogen peroxide,then coconut oil, then antibiotic ointment with pain relief because the pain was so bad it hurt to walk.I ordered Emu oil,Ozonated olive oil,both of the last two would soothe the problem for a short while so I went to the dermatologist and was promptly prescribed steroid cream.This made the problem much worse. So in a final desperate attempt I saw an ad for Perrins Blend in a sidebar on a search engine. I figured "why not?" and to my satisfaction and utter amazement! within 3 short weeks there are little to no symptoms of what has wreak havoc on my life! I ordered the Perrins cream complete at the advisement of a nice man who took my order.  He indicated to me that the regular blend [Perrin’s Blend] may be too strong for my skin.  Well let me just say to all who are in doubt.  JUST TRY IT! PLEASE TRY IT! I ordered my first jar on October 20th 2009.  And today November 16th I have my body back!  I sleep at night! I can wear pants! I am not ashamed for my husband to touch me.I will never be able to show my gratitude in words for Roberta who originally pressed the issue to try it out on herself as a guinea pig.  She is an absolute angel for being so generous with her findings! I spoke with Mrs. Perrin today and expressed how grateful I am for her combining these ingredients and sharing them with the world.Her response was "We take no credit" " God helped us to create it." Now how many corporate companies or Dr's are humble in this way? I think we all know the answer.  I will forever be a customer.
God Bless.
Brandie.

Concerning a Lichen Sclerosis Lesion, involving Perrin’s Blend and the Creme Complete, From Kathy in Michigan
You truly have a marvelous product.  I have been meaning to send you a testimonial, but have not gotten to it as yet.  My condition was with Lichen Sclerouis. (Probably spelled this wrong.)  To make this brief, I had been suffering with this painful condition for about 2 weeks when I ordered your product. Had been to two doctors.  Then I had read many of your postings and found a couple that were similar to my situation so I ordered your product.  I had hoped to receive it on a Friday, but I did not receive it until the following Monday.  That Monday I could not wait to start using Perrin's Blend.  After only one overnight application, my painful lesions had "scabbed" over.  Something that after 2 weeks of applying a cortesone cream was still not healing, in fact, was getting worse day by day.  After 2 days I was totally out of pain.  No more of that razor blade feeling of splitting tissue.  After a week, it was gone.
 
I read many articles and testimonials and this condition and that it is considered chronic.  However, I have not had any relapse or any evidence that I will.
Thank you so very  much!

Concerning Lichen Sclerosis, involving the Creme Complete,
From Marc in Great Britain
Hi James,

I would just like to say how impressed I am with creme complete. My Lichen sclerosis has gone after using the product for just over a month. The White patches have not completely disappeared but almost there. Thanks, your product truly is special.

Concerning Lichen Sclerosis, involving the Creme Complete, From Jo in Portland, OR
Thank you.

    I found your cream several months ago when I was researching Lichen Sclerosis. Thank God one person had sent you a testimony so your website showed up during my search. When I went back to the site to reorder I noticed you now have several testimonies. Feel free to add mine (keeping my full name confidential).
  My first symptoms were intermittent rawness and constant bladder discomfort. When outward symptoms appeared (white, rough and I looked like a head of cauliflower), my naturopathic doctor sent me to a gynecologist who diagnosed lichen sclerosis and gave me the steroid cream (Clobetasol). It worked but the symptoms soon returned. The prognoses for anyone on the steroid cream is grim--increased thinning of tissues until nothing much is left--and that's the good news! I've read horror stories from so many people for whom the pain and misery of the disease progresses in spite of the treatment. I have not touched the steroid cream for several months since I've been using Perrin's Crème Complete and I seem to be doing just fine.
    I also successfully used it to eliminate a ominous-looking skin patch on my arm that was growing back after having it removed by a doctor a few years ago.
    Other uses: this is the absolute best hand cream I've ever used. It makes my very rough hands soft and takes the discomfort of dryness away.

Jo in Portland, OR


I would love to discuss with other women how they use the creams (how often, how long after symptoms are gone, etc.). Have you ever considered adding a discussion forum on your website? That would allow us to share our information without the FDA accusing you of making claims (at least I hope it would). If the FDA ever considers messing with you, please let me know so I can buy a lifetime supply. I truly don't know what I would do without this stuff. 


Concerning Lichen Sclerosis, involving the Creme Complete, From Diana in California
HELLO, MY NAME IS DIANA,
I WOULD LIKE TO TALK ABOUT HOW YOU HAVE HELPED ME SO MUCH,
IM A FIRST TIME USER OF PERRIN'S CREAM COMPLETE, I HAVE ONLY HAD THE PRODUCT FOR 2 DAY'S AND STARTED USING IT ON MY LICHEN SCLEROSIS, RIGHT AWAY I FELT RELIFE, NO BURNING , ITCHING, AND NOW I'M NOT EVEN SCRATCHING AND BLEEDING LIKE I WAS DOING.
I HAVE SEVER LICHEN SCLEROSIS, I HAD TWO BIOPSY, FROM MY DOCTOR, AND BOTH TIMES CAME UP I HAD THE DISEASE, EVERYTIME THEY TOOK A SAMPLE, IT LEFT ME WITH A LESION, AND I SAID NO MORE, CAUSE THEY DIDN'T HEAL, AND I WAS LEFT BEEN WORST THAN I STARTED.
I HAVE NO SEX WITH MY HUSBAND, CAUSE I GET EVEN WORST SCRATCHING AND BLEEDING.
I HAVE ONLY USED THE PERRIN'S CREAM COMPLETE, AND WHAT A BLESSING NOT TO FEEL,LIKE BUG'S ARE CRAWLING IN ME
AGAIN I FELT INSTANCE RELIEF RIGHT A WAY,
PLEASE, ANYONE WHO IS READING THIS, GIVE IT A TRY, I THANK GOD I DID, AND I'M A PRIME EXAMPLE...... I CAN'T BELIEVE  WHAT IT FEEL'S LIKE TO HAVE MY LIFE BACK AGAIN,IT DOES WORK RIGHT AWAY, AND IT STOPPED ALL MY ITCHEN.
I WILL BE ORDERING MORE, CAUSE I DON'T WANT TO BE WITHOUT IT,
I THANK GOD FOR THIS MIRACLE CREAM
PLEASE LET ANYONE WHO WANT'S TO READ WHAT I HAVE TO SAY ABOUT THIS GO AHEAD
I HAVE SUFFERED ALONG TIME WITH LICHEN SCLEROSIS.  (HELP IS ON THE WAY WITH THIS CREAM        MAY THE LORD BLESS YOUR PRODUCT
                      DIANA

Concerning Lichen Sclerosis, involving the Creme Complete, From Jo in England
Hi, I was diagnosed with a posteria prolapse, and while I was being examined for this the specialist found that I had Lichen Sclirosis.
After my op I looked on the internet to see if there was anything I could find to help with L.S. and I found your website. I started with the Creme Complete and then tried the Perrins Blend, but found that the Creme Complete worked better on L.S.
I went back 8wks later for my post op and my specialist could not believe it, He said " Jo you have no sign of L.S. your skin is healthy once again", he was so amazed that he asked me for all your details, so he could read about your amazing creams for himself. I would like to thank you all for this fantastic product, I am no longer sore, and have just got engaged, Thank you all once again.
Jo
Exeter England.

Concerning Lichen Sclerosis, involving the Creme Complete & Perrin’s Blend, From Ann in Canada
I just felt I had to write to extend a God Bless & huge thank you...I too suffer from Lichen Sclerosis & was given Cortisone treatment by the doctor. As I was very much against using any cortisone type product I went onto the internet & by God's good grace & prayers from me I found your website & read the testamonials from other suffers of this condition. I sent away for the Creme Complete & the Perrins Blend after reading Judy's suggestion..
I was suffering so badly with this condition my life had come to a complete stop. I couldn't walk for the discomfort it caused. Even wearing underwear was painful & using toilet tissue even caused pain. I started using the Creme Complete 4 times a day & even though the initial stinging was quite severe I persevered & within about 3 days I found relief no more razor like pains & the lesions were begining to heal. The following week I started using Perrins Blend in the evening before bed & within 24 hours my lesions had almost disappeared & within a week I was completely cured.
I cannot thank you enough..May God bless you & keep helping you with your wonderful work.
With warm regards.
Ann
Victoria. British Columbia. B.C.

Concerning Lichen Sclerosis, involving the Creme Complete, From Katherine in New York
i just wanted to share that I too have had lichens sclerosis for the last two years.  At first I just thought it would go away but after months and months I began to worry that I was suffering from a chronic yeast infection- but nothing I was doing worked.  Finally after looking on the internet i realized that I had lichens sclerosis....  I did not want to go the medical topical creme route- and I was beside myself with anxiety as to if I would ever have a nomal life again.....I saw your ad and what other women wrote and I decided to try it.... just a few days of using perrins blend creme complete I was shedding tears of joy.  My skin was returning to normal, the itching and swelling gone, and i could wear pants again without fearing  that I would be in pain after a few hours. Its been about a month and I see almost complete remission of my symptoms.  It's even removing some age spots from my face!  LOVE this stuff...thank you so much for making this amazing produ!
ct. 

Concerning Lichen Sclerosis, involving the Creme Complete, From Ann in Illinois
hello there!  i just wanted to tell you that i purchased your creme complete for my lichen sclerosus and i cannot believe how well it is working!  i have been misdiagnosed for almost 5 years and after maybe two days i am almost completely asymptomatic!  i was constantly using cortisone creams for years to no avail and your product is a combination of all the recommended ingredients.  it has been a long and difficult road and your creme has given me hope and solution.  you have changed and maybe even saved my life!  this is the best i have felt in years.  i am going to spread the word about your product on the LS blogs.  they know nothing of the disease and for me, western medicine, specifically
the stereriod creams have only exaccerbated my condition.  again, i thank you from the bottom of my heart and cannot wait to share with word of your product to all those that suffer this tragic disease.  many cheers and well wishes,
laurie
IL
age 28

The Ingredients in Perrin's Creme Complete are: 

Grapeseed oil, sweet Almond oil, Organic Castor oil, Organic Olive oil, organic Safflower oil & Soy oil.  Beeswax, Organic Cocoa Butter, Pure Aloe Vera, Vegetable Glycerin, Honey, vegetable derived Emulsifing Wax, Vitamin A,D,E, & C, Resveratrol, CoQ10, N-Acetyl Cysteine, Alpha Lipoic Acid, Grapeseed Extract, Lecithin, Biotin, Peppermint oil, Frankincense oil, Lavender oil, Germanium oil, Lemon oil, corn starch, cream of tartar, sodium bicarbonate, rice flour.

 

N0TES FROM JUDY PERRIN -  
A Frequently Asked Question concerning Lichen Sclerosis.

 
What products do you need for Lichen Sclerosis?  
Many have called and emailed asking what to order for Lichen Sclerosis.
In order to answer this I have written in detail, from my knowledge about the products and from customer input, about this subject.
 Possibly the strongest attack against the disease, Perrin’s Blend, is a sticky ointment    By far it contains the highest concentration of the antioxidants Vitamin C, Alpha Lipoic Acid and N-Acetyl Cysteine (NAC) and Grape-seed extract, and Honey than any of our other products.  For this reason it is possibly the most aggressive against Lichen Sclerosis (LS), yet if person is very raw and irritated, Perrin's Blend might be too harsh to start with because of the burning it might cause.
 If ordering only one product for LS, I suggest starting with Creme Complete, our moisturizing cream highest in antioxidant concentration and also diversity, containing CoQ10 and Resveratrol.   Although it might also burn it would be less intense.  
 Some who have been severely irritated have begun with Nutra Cream, our mildest cream, for a few days before even beginning with Creme Complete.  Nutra Cream, although higher in grape-seed extract than Crème Complete, contains less of the burning antioxidants, such as Vitamin C and NAC.  It is a thicker cream, thereby creating more of a protective shield against urination stinging and itching.  
 I first suggested using Nutra Cream to a mother with a ten-year-old daughter with LS.  Within 3 days of using the Nutra Cream the mother called to say her daughter's intense itching had stopped and the skin looked healthier.  We don’t have this mother’s report on our Web site, but she wrote a testimony for Oprah's forum for LS that you can read by going there.   Another lady who was so badly inflamed that even using bathroom tissue caused bleeding, also started with Nutra Cream and has reported very good results.
 Even though our products don't usually burn on any other skin areas, almost any thing used in such a delicate area might cause burning. Most customers tell us that the burning subsides within 10-20 minutes and then they experience relief.  Some have reported that after a few days it doesn't burn anymore.  We have received only two reports of the products being too intense that they had to stop use.  I wrote about this earlier, which you probably read.
 Many order two products to start with - Perrin’s Blend and Cream Complete - then start with Creme Complete, using it for a few days before introducing Perrin's Blend.  If ordering these two together, be sure to scroll down on the on-line store to get the combination special price.
 Some include Nutra Cream in their order and begin with it (depending on the degree of initial irritation).  If ordering all three products, I suggest starting with Nutra Cream – it can be used anytime relief is needed – to hopefully help with rawness and irritation.    Within 24-48 hours start applying Crème Complete up to 4 times daily for several days, especially applying well at bedtime before graduating to Perrin’s Blend.  Then start using Perrin’s Blend at night.  Perrin's Blend, being in a base or raw honey, is a sticky ointment and would probably be uncomfortable for day use.  It also stains fabrics. The first person, Roberta, who ordered for Lichen Sclerosis (LS) used it at night and then used Creme Complete during the day.
 Although Creme Complete and Nutra Cream both contain some honey, they are spreadable creams for overall use while Perrin's Blend was designed for use in a small area (such as a lesion) and is hard to spread.  It is thick and might need to be thinned by adding a small amount of pure honey for spreading over such a tender area for LS.  A pad may be needed because of the staining.
 -Your order selection should depend on the extent of your condition and how aggressively you want to start.  Because everyone is individual we know that nothing  (not even a prescribed medicines) always work the same for everyone and that no one has a magic formula that brings the same successful results for every single person, yet we are grateful to receive so many positive reports from people being helped.  Hopefully this information will help you decide what you need and you, too, can find relief from this disease.
 
 Judy Perrin


A Special Word from the Perrins concerning Lichen Sclerosis:
 
Several have asked us to contact Roberta, the lady who gave the wonderful report of Perrin’s Blend and Crème Complete helping her Lichen Sclerosis, or to have her contact them.  We understand the reasons of those wanting to do this but in respect for our customers we must abide by a strict policy to never reveal any of their personal information or to contact them for favors.
 
When Roberta first called last year and spoke with Judy Perrin, Judy had never heard of the disease, Lichen Sclerosis.  As Roberta described the condition, Judy discouraged her from using Perrin’s Blend on such a tender area, and discouraged her from buying the products.  Months later, in April of 2009 Roberta contacted Judy once again, inquiring about making a purchase.  Although none of Perrin’s skin blends have been reported as causing a burning sensation on other areas, Judy told her to expect burning in this delicate and inflamed area.   Roberta knew the Perrins had no reports of any customers using their products for Lichen Sclerosis, yet she decided to try Perrin’s Blend and Crème Complete, agreeing to accept all responsibility for the outcome.   After she had such a miraculous report, Judy asked her if she would like to post it on the Web site.  She was ready to do so in order to help others.
 
Since we posted her testimony we know several with this disease have ordered, because we have received several reports from customers using these same two products (Perrin's Blend & Crème Complete) that Roberta ordered.
 
On the positive side:
 
One user told us that, though her condition hadn’t been biopsied, she had been told by two doctors that they believed she had Lichen Sclerosis.  Initially she experienced burning from the products, but after using them for a while all of her symptoms were gone and the doctor confirmed she doesn't have any signs of the disease.
 
Another customer called to tell us of her great improvement after only two days of using Perrin’s Blend and Crème Complete.  She said that the burning was no more than the burning of prescriptions she has used.  She said at first the burning from our products is strong, but after about ten minutes it subsides.  She told us that the area affected by L.S. feels better -- that the products seem to have given a protection against the terrible stinging she was undergoing while urinating, as well as relieving the awful itching she was experiencing.  Hopefully she will keep us updated.
 
On the negative side:
 
Some people are more sensitive to discomfort than others.  We have received reports from two customers who experienced too much burning and have discontinued use of the products in that area.  As mentioned in other places on the website, every ingredient in Perrin’s Blend can be purchased at a health food store and taken internally.  One of the main causes of the burning or stinging sensation is the Vitamin C.
 
We want to help people, so if you have any reports you are willing to share about your situation concerning L.S. and our products, please feel free to call or email. We know this situation is miserable and people need relief; however we want customers to make the choice knowing what others have experienced.
 
 
Our goal is to help others, not to hurt them, which is why Judy discouraged Roberta and she didn't sell to Roberta the first time she called.  It was only after Roberta called again months later that Judy agreed to let her try it.  This is also why we willing share this information with you.   
 
We can't take responsibility for individual reaction.  If a person orders for Lichen Sclerosis, knowing all the pros and cons -- such as an a possible burning reaction, we can’t give refunds for this reason-- just as a pharmacist doesn't give refunds if a medicine doesn't work.  However, their purchases shouldn’t be a total waste, as they can always use the products for other things.
 
Please know that it is our desire for L. S. victims to find relief, yet using must be the decision of each customer.

 

FAQ Frequently Asked Questions about Perrin’s Blend
 
Can I use Perrin's Blend on large areas?
Perrin's Blend is a honey based ointment, making it a sticky paste so it is not easily spread over large areas, but a person can do so if he/she is determined to do so.  It is also burgundy in color due to the grape seed extract which means it can permanently stain clothes, bed linens, etc. so we recommend covering the area with a bandage if staining a fabric is a concern to you.
 
Do I have to keep the lesion covered?
As mentioned above, Perrin's Blend is a sticky honey based ointment and burgundy in color due to the grape seed extract which means it will stain clothes.  Even though we have seen positive results with sporadic application, the best results come when the lesion is in constant contact the Perrin's Blend.  That also means leaving the bandage on during a bath, then not washing it off before reapplying.  Most of the time the lesion needs to be covered to prevent the Perrin's Blend from being rubbed off.  If the place is on your face (where there is less of a chance of the ointment being rubbed off) and you doesn't mind the appearance of the ointment then there may not be as much of a reason to keep the area covered, and a person can keep reapplying during the day.
 
Why is Perrin's Blend so thick?
Perrin's Blend is a high concentration of antioxidants in a base of raw honey, and honey thickens naturally.  We could add more honey which would help with the thickness but that would weaken the formula, so we have chosen not to do this.  The ointment seems to work better when it is so thick it actually has to be pressed onto the area being treated.  Once it makes contact on the skin your body temperature will start to slightly melt the honey, making it softer.  A thicker product runs less, which helps it to stay in place until a bandage can be placed over the area.  If the thickness poses a real problem to you then you can thin the product with pure honey.  Some people choose to do this.
 
What should I use to apply Perrin’s Blend?
First, never use a cotton-tipped applicator.  Cotton fibers will stick to the ointment.  If you prefer not to use your finger, choose a firm applicator -- a wooden paddle or spoon handle is fine).  If Perrin’s Blend tends to stick to the applicator you may want to slightly oil the applicator before applying.
 
Can I get my money back if Perrin's Blend doesn't work?
We don't make claims that Perrin's Blend works for everyone. We relay the testimonies given to us by those who have had success with our products to our customers and those interested in using our products.  Results vary and so does the diligence and consistency of application of the customer,  but we have see more positive results than we ever imagined.   Occasionally we do have a person return the product, but this is very rare (about 1 return in every 300 orders).  If you are highly dissatisfied with the product, return the product to us and we will give you a refund.  We have so few complaints and returns that we haven't developed a definitive policy.  
 
Is Perrin's Blend like Black Salve?
No it isn't.  Black Salve can be extremely invasive and painful, and can leave scars.  There is no ingredient in Perrin's Blend that is similar to blood root, the main ingredient in black slave.  In fact every ingredient in Perrin’s Blend can be bought at a health food store and taken internally. Perrin's Blend is non-invasive and for the most part, painless, and most of the time leaves no scars. There have been some reports of itching and/or tingling associated with using Perrin's Blend but nothing extreme.  In the case of Lichen Sclerosis there has been a burning sensation reported.
 
How long does one container last?
How many applications in one container depend on the size on your lesion.  We have recently had a health food store owner comment that "this stuff [Perrin's Blend] lasts forever".  If you are treating something the size of a pencil eraser then you will probably get 75 - 100 applications out of one 1 oz. container.
 
What are the ingredients in Perrin’s Blend?
The ingredients are:
Raw Honey (local honey directly from the beekeeper),
Grapeseed extract (extremely fine powder with no additives)
Natural Vitamin C powder (pure with no additives)
Natural Vitamin E powder (with natural stabilizers)
Alpha Lipoic Acid powder (pure with no additives)
N-acetyl-Cysteine [NAC]  powder (pure with no additives)
Rice Flour, Magnesium Stearate, Calcium Silicate (natural stabilizers).


All ingredients contain non toxic substance and are actually edible.   No chemicals or petroleum-based substances are ever added to any of Perrin’s products.
 
What is the shelf life of Perrin’s Blend?
We put a two-year expiration date on it, because we know one person had successful results after having it for at least this long.  Honey itself is a natural preservative.
 
Should Perrin’s Blend be refrigerated?
No, refrigeration is not necessary, or even good, for honey.  Store at room temperature in a cabinet to keep it in the dark as much as possible.  Keep it  dry.  Never add water.  Water can cause mold.

 

Grapeseed Extract & Grapeseed Oil 

The medicinal and nutritional value of grapes ( Vitis vinifera ) has been praised for since ancient times. Egyptians consumed this fruit at least 6,000 years ago, and several ancient Greek philosophers praised the healing power of grapes -- usually in the form of wine. European folk healers developed an ointment from the sap of grapevines to cure skin and eye diseases. Grape leaves were used to stop bleeding, inflammation, and pain, such as the kind brought on by hemorrhoids. Unripe grapes were used to treat sore throats and dried grapes (raisins) were used to heal consumption, constipation, and thirst. The round, ripe, sweet grapes, were used to treat a range of health problems including cancer, cholera, smallpox, nausea, eye infections, and skin, kidney, and liver diseases.

Researchers are now discovering that many of the health properties of grapes may actually come from the seeds themselves.

Among other beneficial effects, the active compounds in grape seed are believed to have antioxidant properties. A recent study of healthy volunteers found that supplementation with grape seed extract substantially increased levels of antioxidants in the blood. Antioxidants are substances that destroy free radicals -- damaging compounds in the body that alter cell membranes, tamper with DNA (genetic material), and even cause cell death. Free radicals occur naturally in the body, but environmental toxins (including ultraviolet light, radiation, smoke, certain prescription and non-prescription drugs, and air pollution) can also increase the number of these damaging particles. Free radicals are believed to contribute to the aging process as well as the development of a number of health problems, including heart disease and cancer. Antioxidants found in grape seeds can neutralize free radicals and may reduce or even help prevent some of the damage they cause.  Some studies suggest that grapeseed extract may be as much as 50 times more potent than vitamin C or E in terms of antioxidant activity.  



Some of the substances in grapeseed that are beneficial

Vitamin E, flavonoids, linoleic acid, and compounds called procyanidins (also known as condensed tannins, pycnogenols, and oligomeric proanthocyanidins or OPCs) are highly concentrated in grape seeds. These healthful compounds can also be found in lower concentrations in the skin of the grape. Procyanidins are also found in grape juice and wine, but in lower concentrations. Resveratrol is another of grape's healthful compounds which are related to procyanidins and found mainly in the skins. Resveratrol has gained much popularity as an antioxidant supplement.  Resveratrol has shown to have anti-cancer activity. Resveratrol is a photoalexin produced natually by several plants when under attack by bacteria or fungi.  Phytoalixins are antibacterial and anti-fungal chemicals produced by chemical synthesis.  Resveratrol is found on the skin of grapes but also in the seeds.  In laboratory studies resveratrol has appeared to interfere with cancer cell growth and division and causes some cancer cells to disintegrate at a faster rate than they normally would.  Resveratrol may block enzymes that prolong the the sruvival of several cancer cell types including skin cancer.  As a result tumors may either stop growing or actually shrink  because many of the cancer cells die.
 
In some studies injuries to skin may have healed better when grapeseed extract was applied.  Thorugh several possible effects that include promoting the regrowth of connective tissues, grapeseed extract is believed to encourage faster, stronger healing with less scarring.



Medicinal Uses and Indications

Today, health care professionals use standardized extracts of grape seed to treat a range of health problems related to free radical damage, including blood sugar regulation problems, heart disease, and cancer. Studies in laboratories, animals, and people lend some support to these uses.

Flavonoids found in red wine have been reported to protect the heart. They may inhibit the oxidation of LDL ("bad") cholesterol. (LDL oxidation which can lead to hardening of the arteries or atherosclerosis). Studies have demonstrated a relationship between flavonoid intake (from foods) and reduced risk of death from coronary heart disease.

The Mediterranean diet is comprised of whole grains, fresh fruits and vegetables, fish, olive oil, and moderate, daily wine consumption. In a long-term study of 423 patients who suffered a heart attack, those who followed a Mediterranean diet had a 50 - 70% lower risk of recurrent heart disease compared with controls who received no special dietary counseling. Some researchers believe that some of the beneficial effects of the Mediterranean diet are due to flavonoids found in red wine. (Another well-known theory along these lines is called "The French Paradox." The belief is that drinking wine protects those living in France from developing heart disease at as high a rate as those living in the United States, despite the rich fatty foods they eat.)

Others speculate that the healthful effects of moderate wine consumption are due to its alcohol content and not its flavonoid content. If the flavonoids are contributing to heart protection, then grape seed extracts offer an important alternative to alcohol, particularly given the down sides of drinking alcohol. A third concept is being proposed by a group of researchers who believe that the beneficial effects of wine may be triggered by a complex interaction of alcohol and flavonoids. As the controversy of which ingredient in wine is the most important continues, both grape seed extracts and red wine continue to be promoted for heart health. In addition, several test tube and animal studies confirm that antioxidants from grapes offer cardioprotection in their own right.

It is also important to note that the use of alcohol is not advocated by the American Heart Association and other organizations because of the potential for addiction and the other serious repercussions, such as motor vehicle accidents and the development of hypertension, liver disease, breast cancer, and weight gain. If you do drink red wine, you should have no more than 2 glasses (20 g ethanol) per day.

High cholesterol

A study of 40 people with high cholesterol assessed the effects of grape seed extract, chromium, a combination of both, or placebo for 2 months. The combination of grape seed extract and chromium was more effective than either substance alone or placebo in reducing total and LDL ("bad") cholesterol.

A more recent study tested the effects of a patented grape seed extract on lipid peroxidation (which aids in the formation of "bad" cholesterol) in a group of heavy smokers. Twenty-four healthy male smokers, (aged 50 years or greater) were given either placebo or 2 capsules (75 mg of a grape procyanidin extracts and soy-phosphatidalcholine), twice daily for 4 weeks. "Bad" cholesterol levels (low density lipoprotein or LDL) were lower in those taking the grape seed supplement than those on placebo. The authors concluded that grape seed extract may help prevent cholesterol oxidation and further damage to the cardiovascular system in people who smoke.

High blood pressure

Antioxidants, such as grape seed, help protect blood vessels from damage. Damaged blood vessels can lead to an increased demand on the heart. In several animal studies, a grape seed extract substantially reduced blood pressure. Human studies are needed to determine whether grape seed extract confers the same benefits to people with high blood pressure.

Pancreatitis

In one recent study of only three patients with chronic pancreatitis (inflammation of the pancreas), a commercially available grape seed extract significantly reduced the frequency and intensity of abdominal pain after conventional medications failed to improve symptoms. Further studies are needed to confirm these preliminary findings.

Cancer

Studies have found that grape seed extracts may prevent the growth of breast, stomach, colon, prostate, and lung cancer cells in the laboratory. Grape seed extract may also be effective in preventing damage to human liver cells caused by chemotherapy medications. Antioxidants, such as grape seed extract, have been reported beneficial in cancer prevention. Although grape seed has not been studied in humans for its anticancer effects, the antioxidant properties of grape seed are proven beneficial. 

Other conditions

Health care professionals may recommend grape seed extract for a variety of circulatory ailments (including varicose veins and chronic venous insufficiency). Grape seed may also be used for other diseases related to free radical damage (oxidation), including blood sugar regulation and age-related macular degeneration, an eye disorder that develops with age and can lead to blindness. Grape seed extract may help improve night vision and photophobia (sensitivity to light) as well.

Grape seed extract may also be helpful in those with asthma and allergies. Several studies support the use of proanthocyanidins, such as those found in grape seed, as a supplement for allergic conditions (including airborne and food allergies).


Olive Oil

Here are some of the benefits of Olive Oil when taken internally. 

Olive oil it is a prime component of the Mediterranean Diet. The beneficial health effects of olive oil are due to both its high content of monounsaturated fatty acids and its high content of antioxidative substances. Studies have shown that olive oil offers protection against heart disease by controlling LDL ("bad") cholesterol levels while raising HDL (the "good" cholesterol) levels. (1-3) No other naturally produced oil has as large an amount of monounsaturated as olive oil -mainly oleic acid.

Olive oil is very well tolerated by the stomach. Olive oil's protective function has a beneficial effect on ulcers and gastritis. Olive oil activates the secretion of bile and pancreatic hormones much more naturally than prescribed drugs. Consequently, it lowers the incidence of gallstone formation.

Olive oil and heart disease

Studies have shown that consuming - about 2 tablespoons - of virgin olive oil daily for 1 week showed less oxidation of LDL cholesterol and higher levels of antioxidant compounds, particularly phenols, in the blood.(4)

But while all types of olive oil are sources of monounsaturated fat, EXTRA VIRGIN olive oil, from the first pressing of the olives, contains higher levels of antioxidants, particularly vitamin E and phenols, because it is less processed.

Olive oil is clearly a healing oil. Most people do quite well with it since it does not upset the critical omega 6 to omega 3 ratio and most of the fatty acids in olive oil are actually an omega-9 oil which is monounsaturated.

Olive oil and colon cancer

Spanish researchers suggest that including olive oil in your diet may also offer benefits in terms of colon cancer prevention (5). Their study results showed that rats fed diet supplemented with olive oil had a lower risk of colon cancer than those fed safflower oil-supplemented diets. In fact, the rats that received olive oil had colon cancer rates almost as low as those fed fish oil, which several studies have already linked to a reduction in colon cancer risk.

Topical Uses

For thousands of years olive oil has been used on the skin as a moistuizer and to soften skin.  
Below is a 2005 study involving infants and diaper dermatitis in Dubai Medical Center.

Twelve infants suffering from diaper dermatitis were treated four times daily for 7 days with a mixture containing honey, olive oil and beeswax. The severity of erythema was evaluated on a five-point scale. Three infants had severe erythema and ulceration, four had moderate erythema, and five had moderate erythema with maceration. The initial mean lesion score of 2.91±0.79 declined significantly (p<0.05) to 2.0±0.98 (day 3), 1.25±0.96 (day 5) and 0.66±0.98 (day 7). Candida albicans was isolated initially from four patients, but from only two patients after treatment. This topocal treatment was safe and well-tolerated, and demonstrated clinical and mycological benefits in the treatment of diaper dermatitis. Another study found that a mixture of honey, beeswax and olive oil also inhibited the growth of Staphylococcus and Candida albicans isolated from human specimens.

Olive oil, honey, and beeswax are some of the main ingredients in our skin care products.

 
Sweet Almond Oil-Topical Uses

Sweet almond oil is dry, and easily absorbed by the skin for which it is shown to improve moisture levels and maintain firmness and elasticity. Sweet almond oil can also be used to treat chapped lips and certain mild skin conditions such as rashes, and also eczema. Sweet almond oil can also be taken as a laxative, though this application is not generally recommended.

Sweet almond oil is known for it’s healthy properties and is one of the most popular aromatherapy oils. It has a sweet, nutty scent and is very pale yellow in color. Often sweet almond oil is employed as a massage oil because of its beneficial effect on the skin, adding moisture and combatting dry skin whilst also lending healing properties due to its high mineral content. Sweet almond oil is also an excellent lubricant and many devotees claim it provides their skin with a glow that nothing else can quite match.

Castor oil--Topical Uses

Castor oil has been used therapeutically for hundreds of years, both internally and externally. Applied topically, it has many beneficial effects in a wide range of conditions. Almost 90% of its fatty acid content consists of ricinoleic acid. Such a high concentration of this unusual, unsaturated fatty acid is thought to be responsible for castor oil's healing abilities.  Ricinoleic acid has been shown to be effective in preventing the growth of numerous species of viruses, bacteria, yeasts and molds. (J Am Oil Chem Soc 61;37.323-325.) One study has found that castor oil decreased pain more than ultrasound gel or Vaseline during extracorporeal shock wave application.

 

Beeswax

We use beeswax instead of petroleum because it contains “wax esthers” that also exist in human skin.  It is a natural hydrating agent that increases essential moisture in the skin.  Beeswax has a very low irritation potential and promotes healing and softening of skin and is an antiseptic. Historically, Beeswax was used in Greece to treat abscesses, by the Assyrians to heal wounds, and by the Egyptians for mummification. Numerous scientific tests have been conducted with a variety of bacteria, fungi, viruses and other microorganisms.  A study recently found that a mixture of honey, beeswax and olive oil inhibited the growth of Staphylococcus aureus and Candida albicans isolated from human specimens.

Pure Aloe Vera

Aloe vera has been used since ancient times because of its  benefits for dry and cracked skin, burns, blisters, frostbite, insect bites, and allergic reactions. Many ancient works, including the Bible, refer to the use of aloe. One of the first documented users of aloe vera was Cleopatra.  She is said to have used the gel on her skin as protection from the sun, and to have thought the gel helped to keep her skin young-looking. In fact, the Egyptians may have used aloe vera in their embalming of bodies, among other uses.  In the 10th Century, the Europeans were introduced, where it became an important ingredient in many herbal medicines. By the 16th Century, aloe arrived in the West Indies, where still today it is grown and  harvested.  Today, the gel found in the leaves is used for soothing minor burns, wounds, and various skin conditions like eczema and ringworm. The use of this herbal medicine was popularized in the 1950's in many Western Countries. The gel's effect is nearly immediate, plus it also applies a layer over wounds that is said to reduce the chance of any infection.

Some studies suggest that aloe vera has anti-viral and antibacterial properties.  In one study aloe was mixed with the following viruses: herpes, chickenpox, rabies, and flu. Aloe killed these viruses in 15 minutes. Electron microscopic exam demonstrated that the structures surrounding the viruses were torn apart, thus showing how aloe kills certain viruses in vitro. Dermatologists have shown considerable interest in aloe vera due to its antimicrobial and antibacterial properties. In in vitro studies, marked zones of inhibition (bacteriostatic activity) were shown for Staphylococcus aureus  209, E. coli, Streptococcus pyogenes, Coryenbacterium xerose, Shigella paradysenteriae, Salmonella typhosa, Salmonella schotimuelleri, and Salmonella paratyphi.

Vegetable Glycerin

Vegetable glycerin is a skin-friendly humectant that attracts water into the skin as well as a binding agent that occurs naturally in vegetables.  It is anti-bacterial and works to make the skin supple while fighting dryness and scaling. It is invaluable as a natural source ingredient with emollient like properties which can soften and soothe the skin and it assists the outer epidermis in retaining moisture. It is also a natural preservative.

Vitamin C

Vitamin C is a natural antioxidant and is an essential nutrient for a large number of higher primate species, in nearly all bats (representing 20% of all mammalian species) and a small number of other species, such as the guinea pig and a few species of birds and fish. The presence of ascorbate is required for a range of essential metabolic reactions in all animals and plants. It is made internally by almost all organisms, humans being the most well-known exception. It is widely known as the vitamin whose deficiency causes scurvy in humans. Vitamin C is one of the most common antioxidants.  It recharges other antioxidants like vitamin E.  It helps prevent premature aging and is is required for the synthesis of collagen in the skin.  Collagen can be seen as the foundation of healthy and young looking skin.  Collagen is the main protein of connective tissue in humans making up about 25% of the total protein content.  Vitamin C may also help with UV damage.  A study from Duke University concluded that "Appreciable photoprotection can be obtained from the combination of topical vitamins C and E. We suggest that these natural products may protect against skin cancer and photoaging".  Vitamin C may also contain anti-viral and antibacterial properties.

Vitamin E

Vitamin E is an antioxidant that research has shown to have a variety of benefits for the skin.  Studies have shown vitamin E may help decrease the effects if psoriasis and erythema, in the reduction of stretch marks, in the reduction of scarring from wounds, and it may help to reduce the risk of skin cancer.  A study from Duke University concluded that "Appreciable photoprotection can be obtained from the combination of topical vitamins C and E. We suggest that these natural products may protect against skin cancer and photoaging".

Alpha Lipoic Acid

Recent studies suggest that topical application of alpha lipoic acid may be effective against wrinkles and scars.  If further studies corroborate skin benefits of lipoic acid, it may become one of the mainstays of today's anti-aging skin care. In fact, lipoic acid will be especially welcome in the family of proven wrinkle fighters because it is less irritating than tretinoin (Retin A, Renova) and hydroxy acids. Therefore it can be used in delicate and wrinkle prone area around the eyes.

Alpha lipoic acid is a powerful antioxidant by itself but it also recycles vitamin C and vitamin E.  It can restore the antioxidant properties of these vitamins after they have neutralized free redicals.When taken internally alpha lipoic acid has shown time and again in clinical trials to be successful for protecting cells from free-radical damage.  Free radicals are unstable molecules caused from normal situations like metabolism to unhealthy activities like smoking, and are a major culprit of wrinkling and the loss of firmness associated with normal aging. Alpha lipoic acid could also come to play an important role in the prevention and treatment of chronic degenerative diseases such as diabetes and cardiovascular disease because it is known as a metabolic antioxidant.  Without alpha lipoic acid cells cannot use sugar to produce energy.

N-Acetyl-Cysteine

N-Acetyl Cysteine (or NAC)- NAC is a sulfur containing amino acid that is needed to produce the free radical fighter glutathione and maintain it at adequate levels in cells.  It helps to detoxify the body of chemicals and other poisons and slows the aging process.  Studies have shown that NAC can play a role in the reduction of cancer cells.

Resveratrol

There have been many research reports that have shown resveratrol can prevent or slow down a wide variety of illnesses from Cancer and Alzheimer’s to cardiovascular disease on animals. We use a Micronized Resveratrol powder. The particle size averages between 1 to 4 microns. Most resveratrol supplements currently average between 149 to 224 microns. Micronized Resveratrol powder is estimated to be up to 220% better than most of the regular resveratrol supplements. 


Vitamin A

The body uses vitamin A for maintenance of healthy skin, good vision and a robust immune system.  It is also a free radical fighting antioxidant and therefore is anti-aging. Vitamin A is a carotenoid which is a class of photochemicals that is a fat soluable pigment found in yellow, red, green, and orange vegetables and fruits.  Carotenoids act as anticancer agents.  Alpha lipoic acid, vitamin E, and vitamin C, help conserve carotenoids in tissue.  Research done by Fisher et al in 1998 at the University of Michigan Medical School suggests that higher levels of vitamin A within the skin may prove to have therapeutic and anti-aging value immediately following UV (sun) exposure.  Vitamin A stimulates the removal and replacement of damaged skin components.

 

Vitamin D

Vitamin D can help control the proliferation of skin cells that lead to psoriatic lesions.  Vitamin D deficiency may lead to skin malignancies (skin cancer).  Topically applied Vitamin D may reduce DNA damage in skin that leads to skin cancer.

Biotin

Biotin is also know an as vitiamn H.  It is needed for healthy skin, hair, and nails.  It can be found in many hair care products.  Biotin aids in cell growth, in fatty acid production, in the maetbolism of carbohydrates, fats, and proteins.  In infants, a condition called seborrheic dermatitis, or craddle cap which consists of a dry and flaky scalp may be the result of a deficiency of biotin.

 

Jasmine oil

Jasmine is a sturdy, climbing, evergreen shrub with bright green leaves that grows to be approximately twenty feet tall with white star shaped flowers. These flowers can only be picked at night because they only bloom at night. This beautiful plant can be found in Egypt, Morocco, and the Mediterranean. They were originally found in Peru, Kashmir and China. Jasmine is sought after for its powerful characteristics that aid the body as an anti-depressant, an aphrodisiac, and its confidence boosting qualities it has on the mind. Jasmine’s essential oil is steam distilled from its flowers, it takes huge quantities of petals to prepare one ounce of Jasmine’s essential oil.

Jasmine essential oil has a sweet and floral aroma. It has many healing properties than are very useful it is used as an anti-inflammatory agent, as an antiseptic

Peppermint oil

Peppermint is a natural source of menthol.  Studies have shown that topical application of peppermint stimulates the nerves that detect cold, leading to the cooling sensation. The nerves that perceive pain and itching are depressed.  This leads to the dialation of the blood vessels, which can promote healing.

Lemon oil

Lemon oil is used in natural skin care to cleanse, tone and refresh skin.  Lemon oil tightens puffy skin, reduces enlarged pores and helps disperse pockets of accumulated fluid and impurities.

 

 

 Supporting Research for Grapeseed products.

Bagchi D, Sen CK, Ray SD, et al. Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract. Mutat Res . 2003;523-524:87-97.

Banerjee B, Bagchi D. Beneficial effects of a novel IH636 grape seed proanthocyanidin extract in the treatment of chronic pancreatitis. Digestion . 2001;63(3):203-206.

Belleville J. The French paradox: possible involvement of ethanol in the protective effect against cardiovascular diseases. Nutrition . 2002;18(2):173-177.

Bernstein BJ, Grasso T. Prevalence of complementary and alternative medicine use in cancer patients. Oncology . 2001;15(10):1267-1272; discussion 1272-1278, 1283.

Bielory L. Complementary and alternative interventions in asthma, allergy, and immunology. Ann Allergy Asthma Immunol . 2004;93(2 Suppl 1):S45-54.

Blumenthal M, Riggins C. Popular Herbs in the U.S. Market: Therapeutic Monographs . Austin, Tex: American Botanical Council; 1997.

Brooker S, Martin S, Pearson A, et al. Double-blind, placebo-controlled, randomised phase II trial of IH636 grape seed proanthocyanidin extract (GSPE) in patients with radiation-induced breast induration. Radiother Oncol . 2006;79(1):45-51.

Busserolles J, Gueux E, Balasinska B, et al. In vivo antioxidant activity of procyanidin-rich extracts from grape seed and pine (Pinus maritima) bark in rats. Int J Vitam Nutr Res . 2006;76(1):22-7.

Chan MM, Mattiacci JA, Hwang HS, et al. Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway. Biochem Pharmacol . 2000;60(10):1539-1548.

Chou EJ, Keevil JG, Aeschlimann S, et al. Effect of ingestion of purple grape juice on endothelial function in patients with coronary heart disease. Am J Cardiol . 2001;88(5):553-555.

Faria A, Calhau C, de Freitas V, et al. Procyanidins as antioxidants and tumor cell growth modulators. J Agric Food Chem . 2006;54(6):2392-7.

Fitzpatrick DF, Bing B, Maggi DA, et al. Vasodilating procyanidins derived from grape seeds. Ann N Y Acad Sci . 2002;957:78-89.

Foster S, Tyler VE. Tyler's Honest Herbal . 4th ed. New York: The Haworth Herbal Press; 1999:201-203.

Freedman JE, Parker C 3rd, Li L, et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation . 2001;103(23):2792-2798.

Gruenwalkd J, Brendler T, Jaenicke C, scientific eds; Fleming T, chief ed. PDR for Herbal Medicines . Montvale, NJ: Medical Economics Company; 1998:1224.

Hung LM, Chen JK, Huang SS, et al. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovasc Res . 2000;47(3):549-555.

Hu H, Qin YM. Grape seed proanthocyanidin extract induced mitochondria-associated apoptosis in human acute myeloid leukemia 14.3D10 cells. Chin Med J (Engl). 2006;119(5):417-21.

Joshi SS, Kuszynski CA, Bagchi D. The cellular and molecular basis of health benefits of grape seed proanthocyanidin extract. Curr Pharm Biotechnol . 2001;2(2):187-200.

Kalin R, Righi A, Del Rosso A, et al., Activin, a grape seed-derived proanthocyanidin extract, reduces plasma levels of oxidative stress and adhesion molecules (ICAM-1, VCAM-1 and E-selectin) in systemic sclerosis. Free Radic Res . 2002;36(8):819-25.

Kaur M, Agarwal R, Agarwal C. Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ataxia telangiectasia mutated-p53 activation. Mol Cancer Ther . 2006;5(5):1265-74.

LaValle JB, Krinsky DL, Hawkins EB, et al. Natural Therapeutics Pocket Guide . Hudson, OH:LexiComp; 2000: 451-452.

Natella F, Belelli F, Gentili V, et al. Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans. J Agric Food Chem . 2002;50(26):7720-5.

Nuttall SL, Kendall MJ, Bombardelli E, et al. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther . 1998;23(5):385-389.

Preuss HG, Wallerstedt D, Talpur N, et al. Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study. J Med . 2000;31(5-6):227-246.

Preuss HG, Bagchi D, Bagchi M. Protective effects of a novel niacin-bound chromium complex and a grape seed proanthocyanidin extract on advancing age and various aspects of syndrome X. Ann N Y Acad Sci. 2002;957:250-9.

Rimm EB, Williams P, Fosher K, et al. Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ . 1999 Dec 11;319(7224):1523-8.

Stein JH, Keevil JG, Wiebe DA, et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation . 1999;100(10):1050-1055.

Vigna GB, Costantini F, Aldini G, et al., Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers. Metabolism . 2003;52(10):1250-7.

Vitseva O, Varghese S, Chakrabarti S, et al. Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates. J Cardiovasc Pharmacol . 2005;46(4):445-51.

Waffo-Teguo P, Hawthorne ME, Cuendet M, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape ( Vitis vinifera ) cell cultures. Nutr Cancer . 2001;40(2):173-179.

Yamakoshi J, Kataoka S, Koga T. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis . 1999;142(1):139–149.

Yamakoshi J, Saito M, Kataoka S, et al. Safety evaluation of proanthocyanidin-rich extract from grape seeds. Food Chem Toxicol . 2002;40(5):599-607.

 

 

 

---The information provided on this website should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. We are only relaying information gathered from various sources and various reports and various scientific studies. Information may have errors or be outdated. Some information is from historical sources or represents opinions of the author. It is for research purposes only. The information is "AS IS", "WITH ALL FAULTS". User assumes all risk of use, damage, or injury. You agree that we have no liability for any damages. We are not liable for any consequential, incidental, indirect, or special damages. None of the products sold on this website have been evaluated by the Food and Drug Administration.  None of the products sold on this website are meant to cure, prevent, or diagnose any disease.  Discontinue use of any product on this website if irritation occurs.  We do not suggest anyone use these products instead of seeing a liscensed medical professional.